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Investigations applying IL-1 to stimulate chondrocytes within the OA environment have shown an up-regulation of HIF-1 and LPO levels, with a down-regulation of GSH levels in chondrocytes subjected to IL-1 stimulation [84]

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The safest plan is coordinated among the surgeon, anesthesia team, and prescribing clinician, especially for patients using GLP-1 medications for diabetes, cardiovascular risk reduction, or medically supervised weight management

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